- Tissue Engineering
- Material & Energy Balances
- Momentum Transfer
- Fluid Mechanics
- Heat Transfer
- Process Control
Our areas of expertise include tissue engineering, biomaterials, stem cells and biomechanics. Biomaterials approaches include microsphere-based scaffolds, interpenetrating network hydrogels, colloidal gels, and electrospinning. Our stem cell efforts are focused on umbilical cord stem cells in general and on gene delivery in particular. Early biomechanics studies were focused on temporomandibular joint (TMJ) cartilages, and more recently we have turned our attention to consolidating testing methods for mechanical failure studies of cartilage and hydrogels.
In terms of our tissue engineering and regenerative medicine efforts, we primarily focus on bone and cartilage regeneration, including the TMJ, knee, cranium, and trachea. In addition, our group is also exploring a collaboration in cochlea inner ear hair cell regeneration for hearing restoration.
Our group is best known for our work in the following areas:
Dr. Detamore co-authored a book on TMJ tissue engineering and has authored a pair of invited book chapters on the subject. In addition, he co-organized three TMJ Bioengineering Conferences. He and his group have authored numerous papers on TMJ, and he is a long-time member of the American Society of TMJ Surgeons.
Gradients and interfacial Tissue Engineering
Our group has secured over $2 million in funding from the NIH, NSF and Coulter Foundation in this research area, which has led to two Top-5 cited papers in the journal Tissue Engineering. In addition, our group wrote an invited book chapter on engineering graded tissue interfaces, and Dr. Detamore guest-edited a Special Issue on "Interfacial Bioengineering" for the Annals of Biomedical Engineering in 2010, which was recognized by the journal as the outstanding special issue of the year.
Umbilical Cord Stem Cell
Our group has been recognized as the first to introduce umbilical cord mesenchymal stromal cells to 3D musculoskeletal tissue engineering in our most-cited paper (Bailey et al., Tissue Engineering, 2007). These cells attract the most attention in terms of external requests for protocols and reprints, and not surprisingly a continuously growing number of investigators have started using UCMSCs in musculoskeletal tissue engineering, with a commensurate growth in publications in the field.
- Tissue Engineering
- Regenerative Medicine
- Stem Cells
- American Society of TMJ Surgeons (2006 - Present)
- Fellow of the Midwest Institute for Comparative Stem Cell Biology (2006 - Present)
- Society for Physical Regulation in Biology and Medicine (2006 - Present)
- American Society for Engineering Education (2004 - Present)
- Biomedical Engineering Society (2001 - Present)
- American Institute of Chemical Engineers (1997 - Present)